The Guitar

Saffron Burrows

Melody

Isaach de Bankolé

Roscoe Wasz

Paz de la Huerta

Cookie

Adam Trese

Mr. Laffs

Janeane Garofalo

Dr. Murray

Reg Rogers

Brett

Elizabeth Marvel

Ma Wilder

David Wain

Phone Man

Bill Camp

Pa Wilder

Richard Short

Loser Musician

Mia Kucan

Melody - Young

Lawrence Ballard

Doctor

Ashlie Atkinson

Receptionist

Larry Block

Mr. Faddis

Lori Tan Chinn

Mrs. Tzu

William Leroy

Billy

Virginia Wing

Ms. Li

Chris Bauer

Chief of Surgery (uncredited)

Mark A. Keeton

Guitar Salesman (uncredited)

Sonia Manzano

Lady (uncredited)